4.7 Article

Metal-Free Synthesis of Indole via NIS-Mediated Cascade C-N Bond Formation/Aromatization

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 8, Pages 3841-3851

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00090

Keywords

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Funding

  1. National Natural Science Foundation of China [21172168]
  2. National Basic Research Project [2014CB932201]

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A novel rapid synthesis of indoles from N-Ts-2-alkenylanilines has been described; the reaction involves a NIS-mediated cascade C-N bond formation/aromatization, and a series of indoles with various functional groups have been synthesized in good to excellent yields under Mild conditions without any other additives or catalysts.

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