Journal
DEVELOPMENT
Volume 139, Issue 2, Pages 245-257Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.067074
Keywords
Otic placode; Morphogen; Inner ear; Cochlea; Otocyst
Categories
Funding
- National Institutes of Health
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The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing a group of mechanosensitive sensory organs that mediate hearing and balance. These organs are arranged precisely in space and contain intricately patterned sensory epithelia. Here, we review recent studies of inner ear development and patterning which reveal that multiple stages of ear development - ranging from its early induction from the embryonic ectoderm to the establishment of the three cardinal axes and the fine-grained arrangement of sensory cells - are orchestrated by gradients of signaling molecules.
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