Journal
DEVELOPMENT
Volume 138, Issue 12, Pages 2451-2456Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.058362
Keywords
APETALA 2; Co-repressors; Flower development; LEUNIG; SEUSS; miR172; Arabidopsis
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Funding
- National Science Foundation [IOB0616096, MCB0744752]
- University of Maryland Agricultural Experiment Station
- Direct For Biological Sciences [1021465] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [1021465] Funding Source: National Science Foundation
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Central to the ABCE model of flower development is the antagonistic interaction between class A and class C genes. The molecular mechanisms underlying the A-C antagonism are not completely understood. In Arabidopsis thaliana, miR172 is expressed in the inner floral whorls where it downregulates the class A gene APETALA 2 (AP2). However, what controls this predominantly inner whorl-specific expression of miR172 is not known. We show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer whorls of A. thaliana flowers. The recruitment of LUG/SEU to the miR172 promoters is dependent on AP2, suggesting that AP2 represses the expression of its cognate microRNA. Our study provides new insights into the molecular mechanisms underlying the A-C antagonism and shed light on the transcriptional regulation of miR172 during flower development.
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