Synthesis of Oxazoles by Tandem Cycloisomerization/Allylic Alkylation of Propargyl Amides with Allylic Alcohols: Zn(OTf)2 as π Acid and σ Acid Catalyst

A Zn(OTf)(2)-catalyzed tandem cycloisomerization/allylic alkylation of N-(propargyl)arylamides and allylic alcohols to produce Oxazole derivatives has been successfully developed. The zinc catalyst served as pi acid and also sigma acid in this reaction. The target allylic oxazoles have been transformed into multisubstituted diene Structures, which are potential aggregation-induced emission active Optical materials.