Journal
DEVELOPMENT
Volume 138, Issue 8, Pages 1563-1571Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.056192
Keywords
Neuron-glia interactions; Canoe/AF-6; Drosophila; CNS; Wrapper; DE-cadherin; Nrx-IV; Midline
Categories
Funding
- Spanish Research Council (CSIC)
- Spanish Government [BFU2006-09130, BFU2009-08833]
- CONSOLIDER-INGENIO [CSD2007-00023]
Ask authors/readers for more resources
Vertebrates and insects alike use glial cells as intermediate targets to guide growing axons. Similar to vertebrate oligodendrocytes, Drosophila midline glia ensheath and separate axonal commissures. Neuron-glia interactions are crucial during these events, although the proteins involved remain largely unknown. Here, we show that Canoe (Cno), the Drosophila ortholog of AF-6, and the DE-cadherin Shotgun (Shg) are highly restricted to the interface between midline glia and commissural axons. cno mutant analysis, genetic interactions and co-immunoprecipitation assays unveil Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin. Our results also support additional functions of Cno, independent of adherens junctions, as a regulator of adhesion and signaling events in non-epithelial tissues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available