Journal
DEVELOPMENT
Volume 137, Issue 7, Pages 1017-1033Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.038711
Keywords
Neural development; Neuromuscular junction; Retrograde signaling; Synapse formation
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Funding
- NIH
- MDA
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Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and skeletal muscle fibers and that exhibits a high degree of subcellular specialization. Aided by genetic techniques and suitable animal models, studies in the past decade have brought significant progress in identifying NMJ components and assembly mechanisms. This review highlights recent advances in the study of NMJ development, focusing on signaling pathways that are activated by diffusible cues, which shed light on synaptogenesis in the brain and contribute to a better understanding of muscular dystrophy.
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