Journal
DEVELOPMENT
Volume 137, Issue 3, Pages 373-387Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.031690
Keywords
GFP; Fluorescence imaging; Cell dynamics; Quantitative biology
Categories
Funding
- CNRS
- Association pour la Recherche contre le Cancer
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche
- Human Frontier Science Program Organization
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Embryology and genetics have given rise to a mechanistic framework that explains the architecture of a developing organism. Until recently, however, such studies suffered from a lack of quantification and real-time visualization at the subcellular level, limiting their ability to monitor the dynamics of developmental processes. Live imaging using fluorescent proteins has overcome these limitations, uncovering unprecedented insights that call many established models into question. We review how the study of patterning, cell polarization and morphogenesis has benefited from this technology and discuss the possibilities offered by fluorescence imaging and by the contributions of quantitative disciplines.
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