Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 10, Pages 5296-5301Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00365
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Funding
- National Natural Science Foundation [21132006]
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The first asymmetric total synthesis of (+)-iresin (4), an historically important ent-Drimane sesquiterpene lactone, was realized from aldehyde 3 via cyclic orthoester 6 in 5 steps. Notable transformations in this synthesis include a tandem trifluoroperacetic acid (TEPAA)-mediated Baeyer-Villiger oxidation-olefin epoxidation-epoxy ester cyclization, regioselective Burgess dehydration, and regioselective Fetizon oxidative lactonization.
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