Journal
DEVELOPMENT
Volume 136, Issue 11, Pages 1771-1783Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.030403
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Funding
- Sixth European Union Framework Programme
- 'EPIGENOME' Network of Excellence
- Austrian Science Fund
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Non-coding RNAs (ncRNAs) that regulate gene expression in cis or in trans are a shared feature of prokaryotic and eukaryotic genomes. In mammals, cis-acting functions are associated with macro ncRNAs, which can be several hundred thousand nucleotides long. Imprinted ncRNAs are well-studied macro ncRNAs that have cis-regulatory effects on multiple flanking genes. Recent advances indicate that they employ different downstream mechanisms to regulate gene expression in embryonic and placental tissues. A better understanding of these downstream mechanisms will help to improve our general understanding of the function of ncRNAs throughout the genome.
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