Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 24, Pages 12725-12732Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b02417
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Funding
- National Natural Science Foundation of China [21302023]
- Department of Education of Guangdong Province [2013kjcx0111]
- Innovation and Strong School Project of Guangdong Pharmaceutical University [2014KTSCX120]
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A novel copper-catalyzed regioselective double carbonylation of imidazo[1,2-a]pyridines with N,N-disubstituted acetamide or acetone using molecular oxygen has been described. It has provided a new approach to synthesize 1,2-carbonyl imidazo[1,2-a]pyridines, which are important substrates and intermediates in preparation of fine chemicals. The product shares a skeleton similar to that of Zolpidem, one of the most prescribed drugs in the world. O-18-labeling experiments unambiguously established that the oxygen source of products originated from O-2 rather than H2O.
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