Journal
ACS NANO
Volume 9, Issue 3, Pages 3199-3205Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b00276
Keywords
Fe3O4 nanocrystals; protease-activated; pH mapping; ratiometric fluorescence; smart probe
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Funding
- National Basic Research Program of China [2011CB935800]
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A protease-activated ratiometric fluorescent probe based on fluorescence resonance energy transfer between a pH-sensitive fluorescent dye and biocompatible Fe3O4 nanocrystals was constructed. A peptide substrate of MMP-9 served as a linker between the particle quencher and the chromophore that was covalently attached to the antitumor antibody. The optical response of the probe to activated MMP-9 and gastric cell line SGC7901 tumor cells was investigated, followed by in vivo tumor imaging. Based on the ratiometric pH response to the tumor microenvironment, the resulting probe was successfully used to image the pH of subcutaneous tumor xenografts.
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