Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 15, Pages 7816-7823Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b01249
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Funding
- Natural Science Foundation of China [21302099]
- Natural Science Foundation of Jiangsu Province [BK2012449]
- SRF for ROCS, SEM
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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A general Pd-catalyzed double carbonylation of aryl iodides with secondary or primary amines to produce a-ketoamides at atmospheric CO pressure has been developed. This transformation proceeds successfully even at room temperature and in the absence of any ligand and additive. A wide range of aryl iodides and amines can be coupled to the desired a-ketoamides in high yields with excellent chemoselectivities. Importantly, the current methodology has been demonstrated to be applied in the synthesis of bioactive molecules and chiral a-ketoamides.
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