4.7 Article

Regioselective Synthesis of Multisubstituted Furans via Copper-Mediated Coupling between Ketones and β-Nitrostyrenes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 10, Pages 5364-5368

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00704

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Funding

  1. CSIR, New Delhi [02(0168)/13/EMR-II]
  2. UGC

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A copper-mediated intermolecular annulation of alkyl ketones and beta-nitrostyrenes has been developed for the regioselective synthesis of multisubstituted furan derivatives in good yields. This protocol is applicable to both cyclic and acyclic ketones.

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