Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 10, Pages 4957-4965Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00356
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Funding
- National Natural Science Foundation of China [21172078]
- National Basic Research Program of China (973 Program) [2011CB808600]
- Guangdong Natural Science Foundation [10351064101000000]
- Fundamental Research Funds for the Central Universities [2013ZM0061]
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A copper-catalyzed [4 + 1] annulation between a-hydroxy ketones and nitriles has been developed. The reaction provides a facile and efficient method for the construction of a wide range of highly substituted 3(2H)-furanones, a class of important compounds known to be associated with several biological activities.
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