Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 13, Pages 6784-6793Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00990
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Funding
- Leverhulme Trust [RPG-374]
- Engineering and Physical Sciences Research Council (EPSRC)
- Warwick University URSS scheme
- Warwick University
- EPSRC [EP/L027100/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [1351352, EP/L027100/1] Funding Source: researchfish
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The asymmetric transfer hydrogenation (ATH) of ketones under aqueous conditions using tethered Ru(II)/eta(6)-arene/diamine catalysts is described, as is the ATH of electron-rich substrates containing amine and methoxy groups on the aromatic rings. Although such substrates are traditionally challenging ones for ATH, the tethered catalysts work very efficiently. In the case of amino-substituted ketones, aqueous conditions give excellent results; however, for methoxy-substituted substrates, the more established formic acid/triethylamine system gives superior results.
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