Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 1, Pages 324-329Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b02431
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Funding
- Japan Society for the Promotion of Science
- [1381002900]
- Grants-in-Aid for Scientific Research [13J10638, 26620149, 26410056] Funding Source: KAKEN
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The highly regioselective hydroselenation of N-vinyl lactams has been revealed to successfully afford the corresponding N,Se-acetals as Markovnikov adducts. In the case of terminal N-vinyl lactams, Markovnikov-selective hydroselenation proceeds efficiently in the absence of any catalyst (or additive), owing to the acidity of the selenols. In contrast, the self-promoted hydroselenation is inefficient with internal N-vinyl lactams. In the presence of palladium diacetate (Pd(OAc)(2)), however, the desired hydroselenation of internal N-vinyl lactams proceeds efficiently to afford the corresponding N,Se-acetals.
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