Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 80, Issue 21, Pages 11003-11012Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b02174
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We report a Cu(I)-catalyzed azide-alkyne-allyl halide three-component reaction for a one-pot synthesis of 1,4-disubstituted 5-allyl-1,2,3-triazoles. The allyl moiety provides not only the electrophile but also a coordinating ligand to Cu, which is essential for the reaction to occur under mild conditions. A concise synthesis of a potential drug candidate 1 is realized based on this key reaction.
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