Fluorescence Turn-on Enantioselective Recognition of both Chiral Acidic Compounds and α-Amino Acids by a Chiral Tetraphenylethylene Macrocycle Amine

New chiral tetraphenylethylene (TPE) macrocycles bearing optically pure amine groups were synthesized and found to have a discriminating ability between the two enantiomers of not only chiral acidic compounds but also alpha-amino acids by enantioselective aggregation and aggregation-induced emission (ATE) effects. NMR spectra, including 2D-NOESY, disclosed that the host-guest interaction of the macrocyde receptor played a key role in addition to the acid-base interactions.