Journal
JOURNAL OF ORAL PATHOLOGY & MEDICINE
Volume 45, Issue 7, Pages 516-522Publisher
WILEY-BLACKWELL
DOI: 10.1111/jop.12399
Keywords
CD4(+)T cells; CD8(+)T cells; human telomerase reverse transcriptase; oral lichen planus
Categories
Funding
- National Natural Science Foundation of China [81170972, 81371147]
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BACKGROUND: Oral lichen planus (OLP) is a chronic, T-cell-mediated inflammatory autoimmune disease. Human telomerase reverse transcriptase (hTERT), a catalytic subunit bearing the enzymatic activity of telomerase, may have a unique function in regulating the activation, proliferation, and function of T lymphocytes. The goal of this study was to investigate the expression of hTERT in CD4(+) and CD8(+) T cells from patients with OLP and its correlation with clinical parameter. METHODS: The disease severity of OLP was assessed by RAE (reticular, atrophic, erosive) scoring system. Expressions of hTERT in CD4(+) T cells and CD8(+) T cells isolated from peripheral blood of patients with OLP were detected by real-time PCR, and their correlations with clinical features were analyzed. RESULTS: hTERT mRNA levels in CD4(+) T cells of OLP were significantly lower than that of controls, while the levels in CD8(+) T cells showed no statistical difference. The expression of hTERT in CD4(+) T cells and CD8(+) T cells was neither associated with disease severity nor gender. CD4(+) T cells of OLP patients with the age <= 50 had markedly decreased hTERT levels compared with controls, but CD8(+) T cells did not. CONCLUSIONS: A divergent hTERT pattern between CD4(+) and CD8(+) T cells was implicated in OLP. Decreased hTERT in CD4(+) T cells might be responsible for the immune dysfunction in OLP.
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