Journal
DERMATOLOGY
Volume 224, Issue 2, Pages 168-176Publisher
KARGER
DOI: 10.1159/000338023
Keywords
Vitiligo; Gene expression; Protein expression; Dopamine pathway; Melanocytes
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Funding
- Estonian Ministry of Education [SF0180043s07, SF0180148s08]
- University of Tartu [PARFS 07915]
- Estonian Science Foundation [6576, 7549, 7479]
- European Social Fund [1.2.0401.09-0073]
- European Union
- Archimedes Foundation
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Background: Dopamine has been proven to be toxic for melanocytes. In vitiligo patients the level of dopamine is increased and the functioning of several enzymes participating in the dopamine pathway is changed. Methods: With the use of quantitative real-time polymerase chain reaction and ELISA the expression of genes connected to the dopamine pathway (PAH, PCD, TH, DDC, DBH, PNMT, GPX1, MAOA, MAOB, COMT, DRD1-DADS, VMAT1 and VMAT2) was observed in vitiligo patients' and control subjects' skin and blood. Results: The mRNA expression of GPX1, DDC, MAOA, DRD1 and DRD5 differs in vitiligo skin and the protein level of DDC, MAOA, MAOB, DRD1 and DRD5 is changed in vitiligo patients' skin and/or blood sera. Conclusions: The dopamine pathway probably influences melanogenesis directly or through the melanocortin pathway. We provide new data about changes of expression profile of the dopamine-synthesizing enzyme DDC, the dopamine-degrading enzymes MAOA and MAOB and the D1-like family dopamine receptors in vitiligo skin and blood sera. Copyright (C) 2012 S. Karger AG, Basel
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