Journal
DERMATOLOGY
Volume 222, Issue 2, Pages 109-112Publisher
KARGER
DOI: 10.1159/000323737
Keywords
Acute renal failure; Imiquimod cream; Renal transplantation
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Imiquimod is an immunomodulator of the imidazoquinoline group which possesses antiviral and antitumour activities. Although its mechanism of action has not been entirely elucidated yet, imiquimod 5% cream has been shown to be an efficient, long-lasting and safe therapy for multiple actinic keratoses in non-immunosuppressed patients and in transplant recipients. We report the case of a 44-year-old patient with a third renal transplant who developed an acute tubular necrosis confirmed by renal biopsy after the use of imiquimod 5% cream. The result of a literature search revealed a wide variety of side effects attributable to the use of imiquimod. Copyright (C) 2011 S. Karger AG, Basel
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