Journal
DERMATOLOGY
Volume 217, Issue 4, Pages 321-328Publisher
KARGER
DOI: 10.1159/000155642
Keywords
Scalp; Psoriasis; Calcipotriol; Betamethasone dipropionate
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Funding
- LEO Pharma, Ballerup, Denmark
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Background: Effective and safe products are needed for long-term management of scalp psoriasis. This study investigated the long-term safety and efficacy of a two-compound formulation (calcipotriol 50 mu g/g plus betamethasone dipropionate 0.5 mg/g) for scalp psoriasis. Methods: In this 52-week, international, double-blind study, 869 patients with moderate-to-severe scalp psoriasis were randomized to either a two-compound scalp formulation (n = 429) or calcipotriol ( n = 440). Results: Adverse drug reactions were less frequent in the two-compound group compared with the calcipotriol group (17.2 vs. 29.5%; p < 0.001). Incidences of adverse events possibly associated with long-term corticosteroid use were low in both the two-compound (2.6%) and the calcipotriol (3.0%) groups. Disease was satisfactorily controlled in 92.3% of visits in the two-compound group versus 80.0% in the calcipotriol group ( p < 0.001). Conclusion: The two-compound scalp formulation demonstrated a high level of safety and efficacy in long-term management of scalp psoriasis. Copyright (c) 2008 S. Karger AG, Basel
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