Journal
DERMATOLOGY
Volume 218, Issue 3, Pages 275-277Publisher
KARGER
DOI: 10.1159/000187619
Keywords
Kikuchi-Fujimoto's disease; Epstein-Barr-virus-encoded RNA; Drug-induced hypersensitivity syndrome
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Funding
- Ministry of Education, Sports, Science and Culture of Japan
- Ministry of Health, Labor and Welfare of Japan
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Drug-induced hypersensitivity syndrome (DIHS) is a severe form of drug eruptions associated with viral reactivations. Autoimmune diseases have been reported to develop several months or years after the resolution of DIHS. We describe a 36-year-old man with cervical lymphadenopathy and an erythematous eruption affecting the face and neck, which evolved into clinically evident systemic lupus erythematosus. He had had an episode of DIHS 4 years previously, in which human herpesvirus-6 and Epstein-Barr virus (EBV) were reactivated. Expression of EBV-encoded RNA was detected in the lymph node. On the basis of findings in this patient, we suggest that EBV is pathogenically important in the sequence of events leading to the onset of systemic lupus erythematosus and that patients with a history of DIHS may be at a risk of eventually developing autoimmune diseases. Copyright (C) 2008 S. Karger AG, Basel
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