Journal
DERMATOLOGIC CLINICS
Volume 28, Issue 1, Pages 79-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2009.10.009
Keywords
Basement membrane; Cell adhesion; Cell migration; Laminins
Categories
Funding
- National Institutes of Health [RO1 AR054184]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL092963] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR054184] Funding Source: NIH RePORTER
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The laminins are a secreted family of heterotrimeric molecules essential for basement membrane formation, structure, and function. It is now well established that the alpha 3 subunit of laminins-332, -321, and -311 plays an important role in mediating epidermal-dermal integrity and is essential for the skin to withstand mechanical stresses. These laminins also regulate cell migration and mechanosignal transduction. This article provides an overview of the gene, transcripts, and protein structures of laminin alpha 3. Also discussed are the proposed functions for the alpha 3 subunit-containing laminins.
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