Journal
DENTAL MATERIALS JOURNAL
Volume 31, Issue 3, Pages 489-493Publisher
JAPANESE SOC DENTAL MATERIALS DEVICES
DOI: 10.4012/dmj.2012-008
Keywords
Fluvastatin; Scaffold; Osteogenic
Funding
- Grants-in-Aid for Scientific Research [24390446] Funding Source: KAKEN
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The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-week-old male rats calvaria. All defects of each rat were randomly filled with two of three treatments, specifically: fluvastatin incorporated into a OH disk (Flu-OH), distilled water incorporated into a OH disk, and no treatment. New bone formation was quantitatively analyzed after 7, 14, and 28 days using a micro-computed tomography (micro-CT) system, and histologically observed. Evaluation by micro-CT revealed a significant difference in new bone formation among the three kinds of defect. A highly osteogenic effect was observed in the Flu-OH group. The results showed that the fluvastatin incorporated into a biodegradable GH scaffold promoted osteogenesis in rat calvarial bone, indicating its potential for bone regeneration.
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