Journal
DENTAL MATERIALS JOURNAL
Volume 27, Issue 6, Pages 787-794Publisher
JAPANESE SOC DENTAL MATERIALS DEVICES
DOI: 10.4012/dmj.27.787
Keywords
Histopathological reaction; Calcium phosphate cement; Periodontal bone defect
Funding
- NIDCR NIH HHS [R01 DE011789, R01 DE011789-12, DE11789] Funding Source: Medline
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A calcium phosphate cement (CPC-1), prepared by mixing an equimolar mixture of tetracalcium phosphate and dicalcium phosphate anhydrous with water, has been shown to be highly biocompatible and osteoconductive. A new type of calcium phosphate cement (CPC-2), prepared by mixing a mixture of a-tricalcium phosphate and calcium carbonate with pH 7.4 sodium phosphate solution, was also reported to be highly biocompatible. The objective of the present Study was to compare the osteoconductivities of CPC-1 and CPC-2 when implanted in surgically created defects in the jaw bones of clogs. At, 1 month after surgery, implanted CPC-1 was partially replaced by new bone and converted to bone within 6 months. In comparison, at I month after surgery, the defect filled with CPC-2 was mostly replaced by new bone. Therefore, bone formation in CPC-2-filled pocket was more rapid than in CPC-1-filled pocket. These findings Supported the hypothesis that CPC-2 converted to bone more rapidly than CPC-1.
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