Journal
DENTAL MATERIALS
Volume 27, Issue 6, Pages 581-589Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dental.2011.02.014
Keywords
Zirconia; Soft lithography; Silica coatings; Osteoblasts; Sol-gel
Funding
- Portuguese Science and Technology Foundation [FCT/SFRH/BD/36220/2007, FCT/PTDC/CTM/100120/2008]
- CRUP - Accoes integradas Luso-Espanholas [E46/09]
- Acciones integradas Hispano-Portuguesas, MICINN [HP2008-0075]
- NSF Nanoscale Science and Engineering Center [EEC-0425626]
- U.S. Air Force Office of Scientific Research MURI [F49620-03-1-0421]
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Titanium implants are the gold standard in dentistry; however, problems such as gingival tarnishing and peri-implantitis have been reported. For zirconia to become a competitive alternative dental implant material, surface modification techniques that induce guided tissue growth must be developed. Objectives. To develop alternative surface modification techniques to promote guided tissue regeneration on zirconia materials, for applications in dental implantology. Methods. A methodology that combined soft lithography and sol-gel chemistry was used to obtain isotropic micropatterned silica coatings on yttria-stabilized zirconia substrates. The materials were characterized via chemical, structural, surface morphology approaches. In vitro biological behavior was evaluated in terms of early adhesion and viability/metabolic activity of human osteoblast-like cells. Statistical analysis was conducted using one-way ANOVA/Tukey HSD post hoc test. Results. Isotropic micropatterned silica coatings on yttria-stabilized zirconia substrates were obtained using a combined approach based on sol-gel technology and soft lithography. Micropatterned silica surfaces exhibited a biocompatible behavior, and modulated cell responses (i.e. inducing early alignment of osteoblast-like cells). After 7 d of culture, the cells fully covered the top surfaces of pillar microstructured silica films. Significance. The micropatterned silica films on zirconia showed a biocompatible response, and were capable of inducing guided osteoblastic cell adhesion, spreading and propagation. The results herein presented suggest that surface-modified ceramic implants via soft lithography and sol-gel chemistry could potentially be used to guide periodontal tissue regeneration, thus promoting tight tissue apposition, and avoiding gingival retraction and peri-implantitis. (C) 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
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