Journal
JOURNAL OF NUTRITION
Volume 145, Issue 4, Pages 749-757Publisher
AMER SOC NUTRITION-ASN
DOI: 10.3945/jn.114.204594
Keywords
flaxseed; cholesterol lowering; peripheral artery disease; platelet aggregation; statins
Categories
Funding
- Flax2015
- Canola Council of Canada
- Agri-Food Research and Development Initiative
- Canadian Institutes for Health Research (CIHR)
- Banting and Best Canada Graduate Scholarship Doctoral Award from CIHR
- Heart and Stroke Foundation of Canada
- Patient-Oriented Research Doctoral Scholarship from CIHR
- St. Boniface Hospital Foundation
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Background: Dietary flaxseed lowers cholesterol in healthy subjects with mild biomarkers of cardiovascular disease (CVD). Objective: The aim was to investigate the effects of dietary flaxseed on plasma cholesterol in a patient population with clinically significant CVD and in those administered cholesterol-lowering medications (CLMs), primarily statins. Methods: This double-blind, randomized, placebo-controlled trial examined the effects of a diet supplemented for 12 mo with foods that contained either 30 g of milled flaxseed [milled flaxseed treatment (EX) group; n = 581 or 30 g of whole wheat [placebo (PL) group; n = 52] in a patient population with peripheral artery disease (PAD). Plasma lipids were measured at 0, 1, 6, and 12 mo. Results: Dietary flaxseed in PAD patients resulted in a 15% reduction in circulating LDL cholesterol as early as 1 mo into the trial (P= 0.05). The concentration in the FX group (2.1 +/- 0.10 mmol/L) tended to be less than in the PL group (2.5 +/- 0.2 mmoVL) at 6 mo (P= 0.12), but not at 12 mo (P= 0.33). Total cholesterol also tended to be lower in the FX group than in the PL group at 1 mo (11%, P = 0.05) and 6 mo (11%, P = 0.07), but not at 12 mo (P = 0.24). In a subgroup of patients taking flaxseed and CLM (n = 36), LDL-cholesterol concentrations were lowered by 8.5% 3.0% compared with baseline after 12 mo. This differed from the PL + CLM subgroup (n = 26), which increased by 3.0% 4.4% (P= 0.030) to a final concentration of 2.2 +/- 0.1 mmoVL. Conclusions: Milled flaxseed lowers total and LDL cholesterol in patients with PAD and has additional LDL cholesterol lowering capabilities when used in conjunction with CLMs.
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