Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 39, Issue 1-2, Pages 12-24Publisher
KARGER
DOI: 10.1159/000365587
Keywords
Mild cognitive impairment; Dementia; Diagnosis; Activities of daily living; Functional abilities; Assessment measures
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Funding
- National Institute on Aging (NIA, AFAR, the John A. Haratford Foundation, the Atlantic Philanthropies, the Starr Foundation) [P50 AG16570, K23 AG028727, K08 AG34628]
- Alzheimer's Disease Research Centers of California
- Sidell-Kagan Foundation
- NIA [U01 AG016976]
- NATIONAL INSTITUTE ON AGING [K23AG028727, P50AG016570, K08AG034628, U01AG016976] Funding Source: NIH RePORTER
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Background: Previous cross-sectional studies suggest that assessments of instrumental activities of daily living (IADLs) may be useful for operationalizing the differences in functional deficits seen in mild cognitive impairment (MCI) and dementia. However, their utility for longitudinal changes in IADLs in the transition between MCI and dementia remains unclear. Methods: We analyzed longitudinal IADL data with the Functional Activities Questionnaire (FAQ) in stable (MCI-S; n = 1,318) or progressive (MCI-P; n = 1,108) MCI patients. Results: Larger increases in FAQ scores were seen in the MCI-P group across a 14.5-month interval, but overlapping distributions in the two groups yielded poorer discriminatory power than prior cross-sectional reports. Conclusion: Our findings emphasize the difficulties in operationalizing the criterion of 'essentially intact' IADLs in MCI, which may complicate the interpretation of disease progression in MCI treatment trials. (C) 2014 S. Karger AG, Basel
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