Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 36, Issue 3-4, Pages 242-250Publisher
KARGER
DOI: 10.1159/000351671
Keywords
Alzheimer's disease; Cognitive screening test; Frontotemporal dementia; Neuropsychological tests
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Funding
- National Health and Medical Research Council of Australia [510106]
- ARC Centre of Excellence in Cognition and Its Disorders [CE110001021]
- National Health and Medical Research Council [1016399]
- Motor Neurone Disease Research Institute of Australia [1212]
- Australian Research Council [FF0776229]
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Background/Aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD. (C) 2013 S. Karger AG, Basel
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