Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 33, Issue 4, Pages 273-281Publisher
KARGER
DOI: 10.1159/000339363
Keywords
Dementia with Lewy bodies; Alzheimer's disease; Rapid eye movement sleep behavior disorder; Olfactory dysfunction; Autonomic dysfunction; Early diagnosis; Brain positron emission tomography; Differential diagnosis
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Funding
- Anti-Aging Research Center of Juntendo University School of Medicine
- Ogasawara Foundation for the Promotion of Science and Engineering
- Nihon Medi-Physics
- Grants-in-Aid for Scientific Research [23591729] Funding Source: KAKEN
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Background: Non-motor symptoms are recognized to enable the early detection of Parkinson's disease (PD). It remains unknown when those symptoms appear in dementia with Lewy bodies (DLB). Method: We investigated the prevalence of 15 non-motor symptoms of PD at the onset of memory loss based on a standardized worksheet in 34 patients with DLB, 32 patients with Alzheimer's disease (AD) and 30 normal controls. Results: DLB patients exhibited a significantly higher prevalence of olfactory dysfunction, constipation, increased saliva and signs of rapid eye movement sleep behavior disorder at the onset of memory loss than AD patients and normal controls. Conclusions: Paying attention to non-motor symptoms of PD may help DLB diagnosis in the early stage, especially in terms of its differentiation from AD. Copyright (C) 2012 S. Karger AG, Basel
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