Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 31, Issue 4, Pages 309-316Publisher
KARGER
DOI: 10.1159/000327360
Keywords
Dementia with Lewy bodies; Alzheimer disease; Vascular dementia; Prevalence, age-related; Oldest old
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Funding
- Society for Support of Research in Experimental Neurology, Vienna
- Newcastle NIHR Biomedical Research Centre in Ageing and Age Related Diseases, Newcastle upon Tyne, UK
- Medical Research Council [G0502157, G1100540, G0900652, G0400074, G0700718B] Funding Source: researchfish
- MRC [G0900652, G0502157, G1100540, G0400074] Funding Source: UKRI
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Background: While the prevalence of Alzheimer disease (AD) increases with age, little is known about the frequency of dementia with Lewy bodies (DLB) in the oldest old. A retrospective hospital-based study compared the relative prevalence of DLB among very old individuals. Methods: 1,100 consecutive autopsy cases of demented patients aged over 70 years (mean age: 83.9 +/- 5.4 years) were examined using standardized neuropathological methods and current diagnostic consensus criteria. Results: Evaluation of three age groups (8th-10th decade) showed a significant increase in the relative prevalence of AD with cerebrovascular lesions including mixed dementia, while AD with Lewy body (LB) pathology showed a mild but insignificant age-related increase. Both 'pure' AD and vascular dementia showed a mild but insignificant decline, while DLB (without severe AD pathology) decreased progressively. While the severity of Lewy pathology in DLB slightly decreased with age, concomitant Alzheimer-like pathology increased progressively. Conclusion: Whether DLB in the oldest old represents a distinct group is a matter of discussion, but the relative prevalence of AD with LB in our sample remained fairly stable. Copyright (C) 2011 S. Karger AG, Basel
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