Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 31, Issue 3, Pages 210-217Publisher
KARGER
DOI: 10.1159/000326212
Keywords
Dementia rating scale 2; Mini-mental state examination; Mild cognitive impairment; Parkinson's disease; REM sleep behavior disorder
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Funding
- Fonds de la Recherche en Sante du Quebec
- Canadian Institutes of Health Research
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Background/Aims: Mild cognitive impairment (MCI) is frequent in Parkinson's disease (PD) and idiopathic REM sleep behavior disorder (iRBD). However, only a few studies have evaluated the validity of brief cognitive measures to detect MCI in PD or iRBD using standard diagnostic criteria for MCI. Our aim was to evaluate the validity of the Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (DRS-2) to detect MCI in PD and iRBD. Methods: Forty PD patients and 34 iRBD patients were studied. Receiver operating characteristic curves were created for both tests to assess their effectiveness in identifying MCI in PD and iRBD. Results: In PD, a normality cutoff of 138 on the DRS-2 yielded the best balance between sensitivity (72%) and specificity (86%) with a correct classification of 80%. In iRBD, the optimal normality cutoff was 141 on the DRS-2, with a sensitivity of 90%, a specificity of 71% and a correct classification of 82%. No cutoff for the MMSE was found to have acceptable sensitivity or specificity. Conclusion: The DRS-2 has satisfactory validity to detect MCI in PD or iRBD. The MMSE proved to be invalid as a screening test for MCI in both populations. Copyright (C) 2011 S. Karger AG, Basel
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