Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 32, Issue 2, Pages 79-93Publisher
KARGER
DOI: 10.1159/000330757
Keywords
Cerebrospinal fluid; Delirium; Neurotransmitters; Cytokines; Cortisol; Biomarkers
Categories
Funding
- Research into Ageing
- British Geriatrics Society
- MRC
- Medical Research Council [G0700704B, G108/646] Funding Source: researchfish
- MRC [G108/646] Funding Source: UKRI
Ask authors/readers for more resources
Background: Cerebrospinal fluid (CSF) analysis has great potential to advance understanding of delirium pathophysiology. Methods: A systematic literature review of CSF studies of DSM or ICD delirium was performed. Results: In 8 studies of 235 patients, delirium was associated with: elevated serotonin metabolites, interleukin-8, cortisol, lactate and protein, and reduced somatostatin, beta-endorphin and neuron-specific enolase. Elevated acetylcholinesterase predicted poor outcome after delirium and higher dopamine metabolites were associated with psychotic features. Conclusions: No clear conclusions emerged, but the current literature suggests multiple areas for further investigation with more detailed studies. Copyright (C) 2011 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available