Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 30, Issue 6, Pages 479-485Publisher
KARGER
DOI: 10.1159/000322057
Keywords
Metabolic syndrome; Cognitive impairment; Executive function; Brain lesions; Glucose metabolism
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Funding
- Shimane Institute of Health Science
- Mitsubishi Pharma Research Foundation
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Background/Aims: The aim of this study is to examine whether metabolic syndrome is directly associated with cognitive impairment independent of subclinical ischemic brain lesions. Methods: We examined 1,543 neurologically normal subjects (44-86 years of age). Metabolic syndrome, brain MRI, and cognitive functions including general cognition and executive function were assessed. Results: After adjusting for silent brain lesions and demographic risk factors, metabolic syndrome was an independent risk factor for impairment of executive function (OR = 1.41, 95% CI = 1.17-1.25 for Kohs' Test; OR = 2.25, 95% CI = 1.64-3.07 for Frontal Assessment Battery). Among the components of metabolic syndrome, elevated fasting glucose was the only independent risk factor for impairment of executive function. Conclusion: Metabolic syndrome is associated with impairment of executive function independent of silent brain lesions in the Japanese population. Copyright (C) 2011 S. Karger AG, Basel
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