Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 29, Issue 1, Pages 75-81Publisher
KARGER
DOI: 10.1159/000264630
Keywords
Alzheimer's disease; Amygdala; Entorhinal cortex; Hippocampus; Subjective memory impairment
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Funding
- Alzheimer Forschungsinitiative (AFI)
- German Federal Ministry for Education and Research [O1GI 0102]
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Background/Aims: Subjective memory impairment (SMI) has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI. Methods: Regional volumetric measures were manually traced on 3-Tesla MRI scans. Results: Total brain volume did not differ between the groups. Individuals with SMI had reduced volumes of the hippocampus bilaterally (right p = 0.001; left p < 0.001), the bilateral EC (right p = 0.031, left p = 0.006) and the right amygdala (p = 0.01) compared to the control group. Conclusion: Volume reduction of bilateral hippocampus, bilateral EC and right amygdala supports the concept of SMI as a very early manifestation of AD prior to MCI. SMI may indicate awareness of a degenerative process that can still be functionally compensated. Copyright (C) 2010 S. Karger AG, Basel
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