Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 29, Issue 4, Pages 294-300Publisher
KARGER
DOI: 10.1159/000289814
Keywords
Mild cognitive impairment; Hippocampal volume; Cerebrospinal fluid; beta-Amyloid(42); Total tau
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Funding
- Swedish Research Council [2002-5462, K2002-21P-14359-01A, 09946]
- Handlanden Hjalmar Svenssons Forskningsfond
- Pfannenstills Forskningsstiftelse
- Alzheimerfonden
- Axel Linders Stiftelse
- Stiftelsen Gamla Tjanarinnor
- Sahlgrenska University
- Royal Swedish Academy of Sciences
- Stiftelsen Psykiatriska Forskningsfonden
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Background: Mild cognitive impairment (MCI) is a heterogeneous condition, and the prognosis differs within the group. Recent findings suggest that hippocampal volumetry and CSF biomarkers can be used to predict which MCI patients have an underlying neurodegenerative disorder. Objective: To examine the combined predictive value of hippocampal volume and CSF levels of total tau (T-tau) and beta-amyloid(42) (A beta(42)) in stable and converting MCI patients. The participants (n = 68) included patients with MCI at baseline and who converted to dementia by the time of the 2-year follow-up (n = 21), stable MCI patients (n = 21) and healthy controls (n = 26). Methods: The Goteborg MCI study is a clinically based longitudinal study with biannual clinical assessments. Hippocampal volumetry was performed manually, based on data from the 0.5-tesla MRI investigations at baseline. Baseline CSF levels of T-tau and A beta(42) were measured using commercially available, enzyme-linked immunosorbent assays. Results: The converting MCI group had significantly smaller left hippocampi, lower CSF A beta(42) and higher T-tau compared to both the stable MCI group and the healthy controls. Multivariate analysis revealed that a combination of the variables outperformed the prognostic ability of the separate variables. Conclusions: Hippocampal volumes supplement the prognostic accuracy of CSF A beta(42) and T-tau in MCI. Copyright (C) 2010 S. Karger AG, Basel
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