Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 30, Issue 5, Pages 403-410Publisher
KARGER
DOI: 10.1159/000321352
Keywords
Mild cognitive impairment; Alzheimer's disease; Vascular dementia; Neuropsychology
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Funding
- Axel Linders Stiftelse
- Pfannenstills stiftelse
- Stiftelsen for Gamla Tjanarinnor
- Alzheimerfonden
- Swedish Brain Power
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Objective: To study which cognitive profiles of incipient dementia strongest predict the conversion to Alzheimer's disease (AD) and mixed dementia (MD)/vascular dementia (VaD). Methods: 260 subjects with mild cognitive impairment (MCI) were included in the study and 209 (79%) were followed up after 2 years. At baseline, the subjects were assessed with a neuropsychological battery covering the cognitive domains speed/attention, memory, visuospatial, language and executive functions. Results: After 2 years, 9 subjects were considered normal, 148 had stationary MCI and 47 (23%) had converted to dementia. Twenty subjects were diagnosed with AD, 15 with MD and 9 with VaD. The others were 2 with unspecified dementias and 1 with primary progressive aphasia. Dementia converters had a high proportion of impairment in all cognitive domains. The profiles of incipient AD and MD/VaD differed, with memory, visuospatial and language symptoms preceding AD, and executive and speed/attention symptoms preceding MD/VaD. Conclusions: The risk of converting to dementia is increased when domains in addition to memory are impaired. The incipient AD and MD/VaD profiles differed quite clearly. Considering that the vascular group consisted of a majority of patients with MD, the differences are convincing - vascular disease seems to have an essential impact on cognition. Copyright (C) 2010 S. Karger AG, Basel
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