Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 25, Issue 3, Pages 232-237Publisher
KARGER
DOI: 10.1159/000115847
Keywords
plasma lipid levels; mild cognitive impairment
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Funding
- NCRR NIH HHS [M01 RR000645, RR00645] Funding Source: Medline
- NIA NIH HHS [P01 AG007232-18, K08 AG020856, 1K08AG20856-01, P01 AG007232, P01 AG07232] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000645] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG007232, K08AG020856] Funding Source: NIH RePORTER
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Background: There are conflicting data relating plasma lipids to the risk of Alzheimer's disease (AD). We explored the association of plasma lipids to mild cognitive impairment (MCI), a transitional stage between normal cognition and dementia, in a prospective community-based cohort study among randomly sampled Medicare recipients 6 65 years. Baseline data were collected from 1992 to 1994, follow-up data were collected at 18-month intervals. Methods: Multivariate proportional hazards regression was used to relate plasma lipid levels to incident total MCI, amnestic MCI and nonamnestic MCI in 854 persons without MCI or dementia at baseline. Results: There were 324 cases of incident MCI, 153 cases of amnestic MCI and 171 cases of nonamnestic MCI during 4,189 person-years of follow-up. Higher levels of total cholesterol and LDL were associated with a decreased risk of total MCI in models adjusting for age and sex. However, these associations were attenuated after adjusting for ethnicity, education, APOE epsilon 4 and vascular risk factors. There was no association between lipids and the risk of amnestic or nonamnestic MCI, and there was no effect of lipid-lowering treatment on MCI risk. Conclusions: Plasma lipid levels or lipid-lowering treatment in the elderly are not associated with the risk of MCI. Copyright (c) 2008 S. Karger AG, Basel.
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