Journal
DALTON TRANSACTIONS
Volume 43, Issue 26, Pages 9813-9820Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt00911h
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Funding
- European Union CMST COST Action Functional metal complexes that bind to biomolecules [CM1105]
- Fondazione CRT (Torino, Italy)
- Fondazione CRA (Alessandria, Italy) (project Approcci chemioterapici innovativi per il mesotelioma maligno della pleura)
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This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(IV) octahedral core and one or more bioactive molecules. The platinum(IV) complexes release upon reduction the corresponding cytotoxic Pt(II) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(II) metabolites.
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