Journal
DALTON TRANSACTIONS
Volume 42, Issue 5, Pages 1657-1666Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt32319b
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- Deutsche Forschungsgemeinschaft (DFG) [FOR630]
- Fonds der Chemischen Industrie (FCI)
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Metal complexes with N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry and are now increasingly considered for the development of new chemical tools and metal based drugs. Ruthenium complexes of the type (p-cymene)(NHC)RuCl2 interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B. Pronounced antiproliferative effects could be obtained provided that an appropriate cellular uptake was achieved. Inhibition of tumor cell growth was accompanied by a perturbation of metabolic parameters such as cellular respiration.
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