Journal
DALTON TRANSACTIONS
Volume 42, Issue 4, Pages 918-926Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt31323e
Keywords
-
Categories
Funding
- Australian Postgraduate Award from the University of Western Sydney
- University of Western Sydney
- International Research Initiative Scheme
- Australian Government, through the International Science Linkages (ISL) program
Ask authors/readers for more resources
Twelve metallointercalators of the type [Pt(IL)(AL)](2+), where A(L) is either the R,R or S,S enantiomer of 1,2-diaminocyclopentane (DACP) and IL is either 1,10-phenathroline, 4-methyl-1,10-phenanthroline, 5-methyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5,6-dimethyl-1,10-phenanthroline or 3,4,7,8-tetramethyl-1,10-phenanthroline, were synthesised, characterised and the cytotoxicity to the L1210 cell line was determined. The crystal structures of PHENRRDACP and PHENSS were obtained as monoclinic with a space group of P2(1) (a/angstrom = 11.4966, b/angstrom = 6.6983, c/angstrom = 12.0235) and P2(1) (a/angstrom = 11.5777, b/angstrom = 7.0009, c/angstrom = 12.5079), respectively. The R, R enantiomer of 1,2-diaminocyclopentane (RRDACP) produced the most cytotoxic metallointercalators. The most cytotoxic metallointercalators were 56MERRDACP and 47MERRDACP with IC50 values of 0.16 and 0.17 mu M, respectively, in comparison to cisplatin (1 mu M).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available