Journal
DALTON TRANSACTIONS
Volume 42, Issue 29, Pages 10398-10403Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3dt50910a
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Funding
- Natural Science Foundation of China [20872016, 21172037]
- Natural Science Foundation of Fujian, China [2011J01040]
- Specialized Research Fund for the Doctoral Program of Higher Education [201135141001]
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A series of novel silicon(IV) phthalocyanines conjugated axially with different nucleoside moieties (uridine, 5-methyluridine, cytidine, and 5-N-cytidine derivatives) have been synthesized and evaluated for their photodynamic activities. The uridine-containing compound 1 exhibits the highest photocytotoxicity against HepG2 human hepatocarcinoma cells with an IC50 value as low as 6 nM, which can be attributed to its high cellular uptake and non-aggregated nature in the biological media. This compound shows high affinity toward the mitochondria of HepG2 cells and causes cell death mainly through apoptosis upon illumination. The result indicates that 1 is a highly promising photosensitizer for photodynamic therapy.
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