Journal
DALTON TRANSACTIONS
Volume 42, Issue 5, Pages 1752-1759Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt31783d
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Funding
- National Natural Science Foundation of China [51072087]
- Programs for Science and Technology Development of Shandong Province [2009GG10003031]
- Natural Science Foundation of Shandong Province [2009ZRB01420, BS2012CL015]
- Specialized Research Fund for the Doctoral Program of Higher Education [20113719110001]
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As bimodal magnetic-fluorescent imaging agents, the preparation of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles via a facile homogeneous precipitation method is reported. The results show that these nanoparticles are almost spherical in shape with a diameter of 100-200 nm approximately and a major phase of wurtzite-structured ZnS. The products can successfully label the human hepatocellular carcinoma (HepG2) cells and present low toxicity even at concentrations up to 5 mg mL(-1). Additionally, for the ZnS: Er, Yb, Gd nanoparticles calcinated above 950 degrees C, NIR-to-visible up-conversion fluorescence were obtained, which is believed to be superior to traditional ZnS-based bioimaging agents with down conversion. In MRI studies, they reveal a longitudinal relaxivity rate (r(1)) of 39.46 mM(-1) s(-1) and 57.8 mM(-1) s(-1), respectively, which are much larger than the conventional Gd-DTPA and currently reported Gd-base nanoparticles, suggesting great potential as MRI agents.
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