Journal
DALTON TRANSACTIONS
Volume 42, Issue 48, Pages 16697-16708Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3dt52320a
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Funding
- MIUR [PRIN 2010 BJ23MN_007]
- Progetto FARO (Universita di Napoli Federico II, III tornata)
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In continuation with our studies concerning the synthesis, characterization and biological evaluation of nucleolipidic Ru(III) complexes, a novel design for this family of potential anticancer agents is presented here. As a model compound, a new uridine-based nucleolipid has been prepared, named HoUrRu, following a simple and versatile synthetic procedure, and converted into a Ru(III) salt. Stable formulations of this highly functionalized Ru(III) complex have been obtained by co-aggregation with either the zwitterionic lipid POPC or the cationic DOTAP, which have been subjected to an in-depth microstructural characterization, including DLS, SANS and EPR measurements. The in vitro bioactivity profile of HoUrRu, as a pure compound or in formulation with POPC or DOTAP, reveals high antiproliferative activity against MCF-7 and WiDr human cancer cell lines.
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