Journal
DALTON TRANSACTIONS
Volume 41, Issue 31, Pages 9323-9336Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt12231f
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- CSIR, India
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One pot synthesis of three structurally different Ni(II) thiosemicarbazone complexes 1, 2 and 3 were obtained from the reaction between [NiCl2(PPh3)(2)], 1,2-bis(diphenylphosphino) ethane, and [H-2-(Sal-tsc)]. The obtained products were characterized by various spectral and analytical techniques. From the X-ray crystallographic analysis, an unexpected N-arylation on the coordinated salicylaldehydethiosemicarbazone was found in complex 2. The comparative biological evolutions such as DNA/protein binding, antioxidant, cytotoxicity (MTT, LDH, and NO) and cellular uptake studies have been examined for [Ni(Sal-tsc)(PPh3)] (1) and [(Ni(Sal-tsc))(2)(mu-dppe)] (3). When comparing the cytotoxicity of the complexes, 1 exhibited higher activity than 2 and 3 and by comparing with standard cis-platin, both of them were found to exhibit better activity under identical conditions.
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