Journal
DALTON TRANSACTIONS
Volume 41, Issue 9, Pages 2764-2773Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt12083f
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- Swedish International Development Cooperation Agency (SIDA)
- Swedish Research Council (VR)
- NIH [5SC1GM89558-2]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [SC1GM089558] Funding Source: NIH RePORTER
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Three new ruthenium complexes with bidentate chloroquine analogue ligands, [Ru(eta(6)-cym)(L-1) Cl] Cl (1, cym = p-cymene, L-1 = N-(2-((pyridin-2-yl) methylamino) ethyl)-7-chloroquinolin-4-amine), [Ru(eta(6)-cym)( L-2) Cl] Cl (2, L-2 = N-(2-((1-methyl-1H-imidazol-2-yl) methylamino) ethyl)-7-chloroquinolin-4amine) and [Ru(eta(6)-cym)(L-3) Cl] (3, L-3 = N-(2-((2-hydroxyphenyl) methylimino) ethyl)-7-chloroquinolin-4- amine) have been synthesized and characterized. In addition, the X-ray crystal structure of 2 is reported. The antimalarial activity of complexes 1-3 and ligands L-1, L-2 and L-3, as well as the compound N-(2-(bis((pyridin-2-yl) methyl) amino) ethyl)-7-chloroquinolin-4-amine (L-4), against chloroquine sensitive and chloroquine resistant Plasmodium falciparum malaria strains was evaluated. While 1 and 2 are less active than the corresponding ligands, 3 exhibits high antimalarial activity. The chloroquine analogue L-2 also shows good activity against both the chloroquine sensitive and the chloroquine resistant strains. Heme aggregation inhibition activity (HAIA) at an aqueous buffer/n-octanol interface (HAIR(50)) and lipophilicity (D, as measured by water/n-octanol distribution coefficients) have been measured for all ligands and metal complexes. A direct correlation between the D and HAIR(50) properties cannot be made because of the relative structural diversity of the complexes, but it may be noted that these properties are enhanced upon complexation of the inactive ligand L-3 to ruthenium, to give a metal complex (3) with promising antimalarial activity.
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