Journal
DALTON TRANSACTIONS
Volume 41, Issue 17, Pages 5260-5271Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt12298g
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Funding
- University of Kalyani
- FEDER
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/34835/2007, PEst/QUI/UI100/2011]
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This paper describes the activity of a Schiff base ligand, derived from pyridoxal, as a promising fluorescence probe for biologically important Zn(II) ion sensing. This is the first report of a vitamin based ligand as a fluorescent probe for sensing Zn(II) ions. The Schiff base H(2)pydmedpt, derived from the condensation of pyridoxal (pyd) and N,N-bis[3-aminopropyl]methylamine (medpt), exhibits around a 325-fold increase in fluorescence quantum yield due to zinc triggered fluorescence switching. The response is specific for Zn(II) ions, and remains unaffected by the presence of alkali and alkaline earth metals but is suppressed to varying degrees by transition metal ions. The corresponding Zn(II)-complex, [Zn(pydmedpt], is isolated. The DFT optimized structure of the complex is compatible with elemental analysis, mass spectrometry, FT-IR, electronic and NMR spectra. The isolated complex, having pK(a) values of similar to 5.3 and similar to 5, is a moderate intercalator for DNA with an apparent binding constant of 2.3 x 10(6) M-1. The complex also shows insulin-enhancing activity at par with other reported complexes, with an IC50 value of 0.65 with respect to ZnSO4.
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