Journal
DALTON TRANSACTIONS
Volume 41, Issue 45, Pages 13862-13875Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt30662j
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Funding
- Deutsche Forschungsgemeinschaft [FOR 630]
- Fonds der Chemischen Industrie
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A series of eta(4)-acyloxycyclohexadiene-Fe(CO)(3) complexes was prepared and fully characterized by spectroscopic methods including single crystal X-ray diffraction. For this purpose a new synthetic access to differently acylated 1,3- and 1,5-dienol-Fe(CO)(3) complexes was developed. The enzymatically triggered CO release from these compounds was monitored (detection of CO through GC and/or by means of a myoglobin assay) and the anti-inflammatory effect of the compounds was assessed by a cellular assay based on the inhibition of NO-production by inducible NO synthase (iNOS). It was demonstrated that the properties (rate of esterase-triggered CO release, iNOS inhibition, cytotoxicity) of the complexes strongly depend on the substitution pattern of the pi-ligand and the nature of the acyloxy substituent.
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