4.7 Article

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Journal

DALTON TRANSACTIONS
Volume 41, Issue 13, Pages 3720-3725

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2dt12399a

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A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

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